Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection

In this study, SARS-CoV-2 infection before vaccination was found to elicit mucosal IgA, which protects against infection. Vaccines inducing mucosal immunity may be important for preventing infection.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2022-10, Vol.387 (14), p.1333-1336
Hauptverfasser:	Havervall, Sebastian, Marking, Ulrika, Svensson, Julia, Greilert-Norin, Nina, Bacchus, Philip, Nilsson, Peter, Hober, Sophia, Gordon, Max, Blom, Kim, Klingström, Jonas, Åberg, Mikael, Smed-Sörensen, Anna, Thålin, Charlotte
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies antibody detection antibody response Confidence intervals controlled study Coronavirus coronavirus disease 2019 coronavirus spike glycoprotein correlation coefficient Correspondence COVID-19 cycle threshold value follow up health care personnel human Humans immunity Immunoglobulin A immunoglobulin G immunology infection risk Infections Infectious Disease Letter major clinical study Mucosal immunity Neutralizing neutralizing antibody nonhuman polymerase chain reaction prevention and control risk reduction SARS-CoV-2 SARS-CoV-2 Omicron SARS-CoV-2 vaccine screening Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein spike protein vaccinee Vaccines Viral Viral Envelope Proteins Viral Infections virology virus antibody virus envelope protein virus replication
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In this study, SARS-CoV-2 infection before vaccination was found to elicit mucosal IgA, which protects against infection. Vaccines inducing mucosal immunity may be important for preventing infection.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMc2209651