Hormone replacement in premenopausal women treated with bilateral oophorectomy for ovarian cancer - a nationwide population-based study

To study the extent of hormone replacement therapy (HRT) dispensing in premenopausal women after being treated with bilateral salpingo-oophorectomy (BSOE) for ovarian cancer (OC). Nationwide population- and register-based cohort study including women 18-50 years old, registered in The Swedish Qualit...

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Veröffentlicht in:Gynecologic oncology 2022-12, Vol.167 (3), p.476-482
Hauptverfasser: von Kartaschew, Åsa Ehlin, Dahm-Kähler, Pernilla, Rodriguez-Wallberg, Kenny A, Holmberg, Erik, Rådestad, Angelique Flöter
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Sprache:eng
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Zusammenfassung:To study the extent of hormone replacement therapy (HRT) dispensing in premenopausal women after being treated with bilateral salpingo-oophorectomy (BSOE) for ovarian cancer (OC). Nationwide population- and register-based cohort study including women 18-50 years old, registered in The Swedish Quality Register for Gynecological Cancer (SQRGC), where BSOE was performed due to epithelial (EOC) and non-epithelial ovarian cancers (NEOC) or borderline ovarian tumor (BOT) between 2008 and 2014. Data on HRT dispensing was obtained from the National Prescribed Drug Register analyzed at semi-annual intervals from surgery until end of follow-up December 2015, including a logistic regression analysis. A cohort of 664 women were identified with OC, whereas 396 women had an EOC, 61 a NEOC and 207 a BOT. At surgery 49% of the women were ≤44 years. HRT dispensed to the total cohort varied between 32% and 41% the first five years after surgery. During follow-up at first 0.5-1 year 51% of the women
ISSN:0090-8258
1095-6859
1095-6859
DOI:10.1016/j.ygyno.2022.09.027