Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide a...

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Veröffentlicht in:	Leukemia 2022-12, Vol.36 (12), p.2835-2844
Hauptverfasser:	Berndt, Sonja I., Vijai, Joseph, Benavente, Yolanda, Nieters, Alexandra, Wang, Zhaoming, Smedby, Karin E., Kleinstern, Geffen, Morton, Lindsay M., Teras, Lauren R., Adami, Hans-Olov, Anderson, Kenneth C., Ansell, Stephen M., Bassig, Bryan, Bhatti, Parveen, Birmann, Brenda M., Boffetta, Paolo, Brennan, Paul, Cannon-Albright, Lisa A., Chang, Ellen T., Chiu, Brian C. H., Clavel, Jacqueline, Cocco, Pierluigi, Cox, David G., Curtin, Karen, De Vivo, Immaculata, Diepstra, Arjan, Diver, W. Ryan, Edlund, Christopher K., Foretova, Lenka, Gabbas, Attilio, Ghesquières, Hervé, Glenn, Martha, Glimelius, Bengt, Gu, Jian, Habermann, Thomas M., Haioun, Corinne, Hofmann, Jonathan N., Holford, Theodore R., Holly, Elizabeth A., Hutchinson, Amy, Izhar, Aalin, Jackson, Rebecca D., Jarrett, Ruth F., Kaaks, Rudolph, Kane, Eleanor, Kolonel, Laurence N., Kong, Yinfei, Kricker, Anne, Lan, Qing, Lawrence, Charles, Li, Dalin, Magnani, Corrado, Maynadie, Marc, McKay, James, Monnereau, Alain, North, Kari E., Onel, Kenan, Purdue, Mark P., Riboli, Elio, Riby, Jacques, Roman, Eve, Salles, Gilles, Sborov, Douglas W., Severson, Richard K., Shanafelt, Tait D., Smith, Martyn T., Smith, Alexandra, Song, Kevin W., Southey, Melissa C., Staines, Anthony, Sutherland, Heather J., Tkachuk, Kaitlyn, Thompson, Carrie A., Tilly, Hervé, Travis, Ruth C., Turner, Jenny, Vachon, Celine M., Vajdic, Claire M., Van Den Berg, Anke, Van Den Berg, David J., Vermeulen, Roel C. H., Vineis, Paolo, Wang, Sophia S., Weiderpass, Elisabete, Weinstein, Stephanie, Ye, Yuanqing, Yeager, Meredith, Yu, Kai, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Ziv, Elad, Sampson, Joshua, Chatterjee, Nilanjan, Offit, Kenneth, Cozen, Wendy, Wu, Xifeng, Cerhan, James R., Chanock, Stephen J., Slager, Susan L., Rothman, Nathaniel
Format:	Artikel
Sprache:	eng
Schlagworte:	45/43 45/61 631/67/2324 631/67/68 692/499 Association analysis Cancer Research Case-Control Studies Chromosome 10 Critical Care Medicine Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Germ Cells Hematology Heritability Heterogeneity Humans Intensive Internal Medicine Life Sciences Lymphoma Lymphoma, Non-Hodgkin - genetics Malignancy Medicine Medicine & Public Health Non-Hodgkin's lymphoma Oncology Polygenic inheritance Polymorphism, Single Nucleotide Risk analysis Risk Factors Santé publique et épidémiologie
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Zusammenfassung:	Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci ( P
ISSN:	0887-6924 1476-5551 1476-5551
DOI:	10.1038/s41375-022-01711-0