Neurodevelopmental correlates of caudate volume in children born at risk of neonatal hypoglycaemia

Neurodevelopmental correlates of caudate volume in children born at risk of neonatal hypoglycaemia

Background Neonatal hypoglycaemia can lead to brain damage and neurocognitive impairment. Neonatal hypoglycaemia is associated with smaller caudate volume in the mid-childhood. We investigated the relationship between neurodevelopmental outcomes and caudate volume and whether this relationship was i...

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Veröffentlicht in:Pediatric research 2023-05, Vol.93 (6), p.1634-1641
Hauptverfasser: Kennedy, Eleanor, Nivins, Samson, Thompson, Benjamin, McKinlay, Christopher J. D., Harding, Jane
Format: Artikel
Sprache:eng
Schlagworte:
Child
Clinical Research Article
Executive function
Female
Gestational Age
Humans
Hypoglycemia
Hypoglycemia - complications
Infant, Newborn
Infant, Newborn, Diseases
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Prospective Studies
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Zusammenfassung:Background Neonatal hypoglycaemia can lead to brain damage and neurocognitive impairment. Neonatal hypoglycaemia is associated with smaller caudate volume in the mid-childhood. We investigated the relationship between neurodevelopmental outcomes and caudate volume and whether this relationship was influenced by neonatal hypoglycaemia. Methods Children born at risk of neonatal hypoglycaemia ≥36 weeks’ gestation who participated in a prospective cohort study underwent neurodevelopmental assessment (executive function, academic achievement, and emotional-behavioural regulation) and MRI at age 9–10 years. Neonatal hypoglycaemia was defined as at least one hypoglycaemic episode (blood glucose concentration
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-022-02410-3