Worries and Psychological Well-Being in Potential Hematopoietic Stem Cell Donors Before Donation—A Swedish National Study

•Some potential donors of hematopoietic stem cells, both related and unrelated, are extra vulnerable to psychological risks.•In a Swedish national cohort study, 12% (n = 210) reported worrying greatly about themselves as potential hematopoietic stem cells donors.•Great worry about oneself as a potential hematopoietic stem cell donor, lower age, and female sex were related to increased anxiety and lower mental health, but not depression. The physical risks involved in donating hematopoietic stem cells have been thoroughly studied, but little is known about the psychological risks potential donors might face before donation. The aim of this study was to describe potential the pre-donation worries and psychological well-being of hematopoietic stem cell donors and investigate possible associations between donor characteristics and psychological well-being. In a cross-sectional, national cohort study, we describe pre-donation worries and psychological well-being and investigate possible associations between donor characteristics and psychological well-being. A questionnaire was sent to prospective adult hematopoietic stem cells donors. The study included 210 participants, 47% of whom were related and 53% unrelated to the recipient. Of the participants, 39% reported great worry about the recipient and 12% great worry about themselves as potential donors. Symptoms of anxiety were expressed by 21%, whereas symptoms of depression were uncommon and perceived general mental health was slightly lower than in the Swedish population. Great worry about oneself, lower age, and female sex were related to increased anxiety and lower mental health. This study highlighted that some potential donors report high levels of pre-donation worry and that greater worry about oneself, lower age, and female sex are associated with lower psychological well-being. Although further studies are needed to investigate this psychological risk over time, it is clear that some potential donors are particularly vulnerable.