Childhood cancer and hematological disorders negatively affect spermatogonial quantity at diagnosis: a retrospective study of a male fertility preservation cohort

Childhood cancer and hematological disorders negatively affect spermatogonial quantity at diagnosis: a retrospective study of a male fertility preservation cohort

Abstract STUDY QUESTION What is the impact of cancer or hematological disorders on germ cells in pediatric male patients? SUMMARY ANSWER Spermatogonial quantity is reduced in testes of prepubertal boys diagnosed with cancer or severe hematological disorder compared to healthy controls and this reduc...

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Veröffentlicht in:Human reproduction (Oxford) 2023-03, Vol.38 (3), p.359-370
Hauptverfasser: Masliukaite, Ieva, Ntemou, Elissavet, Feijen, Elizabeth A M, van de Wetering, Marianne, Meissner, Andreas, Soufan, Alexandre T, Repping, Sjoerd, Kremer, Leontien M C, Jahnukainen, Kirsi, Goossens, Ellen, van Pelt, Ans M M
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Child
Cryopreservation
Fertility Preservation - methods
Hematologic Diseases
Humans
Hydroxyurea
Male
Medicin och hälsovetenskap
Neoplasms
Original
Retrospective Studies
Spermatogonia
Testis
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Beschreibung
Zusammenfassung:Abstract STUDY QUESTION What is the impact of cancer or hematological disorders on germ cells in pediatric male patients? SUMMARY ANSWER Spermatogonial quantity is reduced in testes of prepubertal boys diagnosed with cancer or severe hematological disorder compared to healthy controls and this reduction is disease and age dependent: patients with central nervous system cancer (CNS tumors) and hematological disorders, as well as boys
ISSN:0268-1161
1460-2350
1460-2350
DOI:10.1093/humrep/dead004