Different Intravenous Administration Techniques for 5-Fluorouracil Pharmacokinetics and Pharmacodynamic Effects
The pharmacokinetics after 20min intravenous infusion or a 2min bolus (push) injectiof 5-fluorouracil (500 mg/m2) were studied in 14 colorectal cancer patients. Treatment effects and toxicity related to the administration technique of 5-fluorouracil were retrospectively analysed in 198 colorectal ca...
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Veröffentlicht in: | Acta oncologica 1996, Vol.35 (2), p.207-212 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The pharmacokinetics after 20min intravenous infusion or a 2min bolus (push) injectiof 5-fluorouracil (500 mg/m2) were studied in 14 colorectal cancer patients. Treatment effects and toxicity related to the administration technique of 5-fluorouracil were retrospectively analysed in 198 colorectal cancer patients. The AUC after bolus injection was 6158 ± 874 μmol/1*min compared to 3 355 ± 428μmol/1*min after short-time infusion of 5-fluorouracil (p |
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ISSN: | 0284-186X 1651-226X |
DOI: | 10.3109/02841869609098503 |