Different Intravenous Administration Techniques for 5-Fluorouracil Pharmacokinetics and Pharmacodynamic Effects

The pharmacokinetics after 20min intravenous infusion or a 2min bolus (push) injectiof 5-fluorouracil (500 mg/m2) were studied in 14 colorectal cancer patients. Treatment effects and toxicity related to the administration technique of 5-fluorouracil were retrospectively analysed in 198 colorectal ca...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta oncologica 1996, Vol.35 (2), p.207-212
Hauptverfasser: Larsson, Per-Anders, Carlsson, Göran, Gustavsson, Bengt, Graf, Wilhelm, Glimelius, Bengt
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The pharmacokinetics after 20min intravenous infusion or a 2min bolus (push) injectiof 5-fluorouracil (500 mg/m2) were studied in 14 colorectal cancer patients. Treatment effects and toxicity related to the administration technique of 5-fluorouracil were retrospectively analysed in 198 colorectal cancer patients. The AUC after bolus injection was 6158 ± 874 μmol/1*min compared to 3 355 ± 428μmol/1*min after short-time infusion of 5-fluorouracil (p
ISSN:0284-186X
1651-226X
DOI:10.3109/02841869609098503