Expression of neurotrophin-3 mRNA in the rat visual cortex and hippocampus is influenced by environmental conditions

Environmental enrichment results in structural changes in the brain. Recent findings indicate involvement of neurotrophins in neuronal plasticity. This study examined the effect of environmental complexity on the levels of neurotrophin-3 (NT-3) mRNA in the rat visual cortex and hippocampus, studied...

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Veröffentlicht in:	Neuroscience letters 1996-11, Vol.218 (2), p.107-110
Hauptverfasser:	Torasdotter, Marita, Metsis, Madis, Henriksson, Bengt G., Winblad, Bengt, Mohammed, Abdul H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry and metabolism Biological and medical sciences Central nervous system Environmental complexity Environmental Exposure Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - metabolism In Situ Hybridization Learning Male Medicin och hälsovetenskap Nerve Growth Factors - metabolism Neurotrophin 3 Plasticity Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Vertebrates: nervous system and sense organs Visual cortex Visual Cortex - metabolism
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Beschreibung
Zusammenfassung:	Environmental enrichment results in structural changes in the brain. Recent findings indicate involvement of neurotrophins in neuronal plasticity. This study examined the effect of environmental complexity on the levels of neurotrophin-3 (NT-3) mRNA in the rat visual cortex and hippocampus, studied by in situ hybridization. Rats housed in groups in a complex, stimulating environment had significantly higher levels of NT-3 mRNA in the visual cortex and the hippocampus than rats housed in individual cages without stimulating objects. These results indicate a possible role for NT-3 in synaptic plasticity.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/S0304-3940(96)13127-X