Long-term dental development in children after treatment for malignant disease
A radiographic dental examination was performed in 16 children conditioned with total body irradiation (TBI) and cyclophosphamide (CY) prior to bone marrow transplantation (BMT), and in 52 children treated with multiagent chemotherapy. For each child, three age- and sex-matched healthy controls were...
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| Veröffentlicht in: | European journal of orthodontics 1997-04, Vol.19 (2), p.151-159 |
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| container_title | European journal of orthodontics |
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| creator | Näsman, Margareta Forsberg, Carl-Magnus Dahllöf, Göran |
| description | A radiographic dental examination was performed in 16 children conditioned with total body irradiation (TBI) and cyclophosphamide (CY) prior to bone marrow transplantation (BMT), and in 52 children treated with multiagent chemotherapy. For each child, three age- and sex-matched healthy controls were selected. Evaluation of disturbances in dental development and tooth size was based on planimetric measurements of mandibular teeth on panoramic radiographs. Short V-shaped roots were diagnosed in 94 per cent of the children treated with TBI/CY compared with 19 per cent in the chemotherapy group (P |
| doi_str_mv | 10.1093/ejo/19.2.151 |
| format | Article |
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For each child, three age- and sex-matched healthy controls were selected. Evaluation of disturbances in dental development and tooth size was based on planimetric measurements of mandibular teeth on panoramic radiographs. Short V-shaped roots were diagnosed in 94 per cent of the children treated with TBI/CY compared with 19 per cent in the chemotherapy group (P<0.001). Children receiving TBI/CY also exhibited a pronounced reduction in tooth size compared with the controls. Reductions varied from 19 per cent in incisors to 39 per cent in the second molars. In the chemotherapy group the corresponding values were 7 and 15 per cent respectively. When comparing crown/root ratios, the indices for incisors, canines (P<0.05) and molars (P<0.01) in the BMT group were significantly higher than the corresponding values in the control group. This indicates that the reduction in root size was more pronounced than the reduction in crown size. The premolars in the BMT group exhibited a similar reduction in crown and root size. All developing teeth were affected by multiagent chemotherapy and radiation therapy. The most severe disturbances were found in children treated with TBI/CY at a young age.</description><identifier>ISSN: 0141-5387</identifier><identifier>EISSN: 1460-2210</identifier><identifier>DOI: 10.1093/ejo/19.2.151</identifier><identifier>PMID: 9183064</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Age Factors ; Antineoplastic Agents, Alkylating - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Bicuspid - drug effects ; Bicuspid - pathology ; Bicuspid - radiation effects ; Bone Marrow Transplantation ; Case-Control Studies ; Child ; Cuspid - drug effects ; Cuspid - pathology ; Cuspid - radiation effects ; Cyclophosphamide - therapeutic use ; Female ; Hematologic Neoplasms - drug therapy ; Hematologic Neoplasms - radiotherapy ; Humans ; Incisor - diagnostic imaging ; Incisor - drug effects ; Incisor - pathology ; Male ; Mandible ; Medicin och hälsovetenskap ; Molar - drug effects ; Molar - pathology ; Molar - radiation effects ; Neoplasms - drug therapy ; Neoplasms - radiotherapy ; Neoplasms - therapy ; Odontogenesis - drug effects ; Odontogenesis - radiation effects ; Odontometry ; Radiography, Panoramic ; Tooth Crown - diagnostic imaging ; Tooth Crown - drug effects ; Tooth Crown - pathology ; Tooth Root - drug effects ; Tooth Root - pathology ; Tooth Root - radiation effects ; Whole-Body Irradiation</subject><ispartof>European journal of orthodontics, 1997-04, Vol.19 (2), p.151-159</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-77c4280c97e00ca0c5bb80c7b8c44aa664c29da9ede1a86d11d176634c5818c73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9183064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1928975$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Näsman, Margareta</creatorcontrib><creatorcontrib>Forsberg, Carl-Magnus</creatorcontrib><creatorcontrib>Dahllöf, Göran</creatorcontrib><title>Long-term dental development in children after treatment for malignant disease</title><title>European journal of orthodontics</title><addtitle>European Journal of Orthodontics</addtitle><description>A radiographic dental examination was performed in 16 children conditioned with total body irradiation (TBI) and cyclophosphamide (CY) prior to bone marrow transplantation (BMT), and in 52 children treated with multiagent chemotherapy. For each child, three age- and sex-matched healthy controls were selected. Evaluation of disturbances in dental development and tooth size was based on planimetric measurements of mandibular teeth on panoramic radiographs. Short V-shaped roots were diagnosed in 94 per cent of the children treated with TBI/CY compared with 19 per cent in the chemotherapy group (P<0.001). Children receiving TBI/CY also exhibited a pronounced reduction in tooth size compared with the controls. Reductions varied from 19 per cent in incisors to 39 per cent in the second molars. In the chemotherapy group the corresponding values were 7 and 15 per cent respectively. When comparing crown/root ratios, the indices for incisors, canines (P<0.05) and molars (P<0.01) in the BMT group were significantly higher than the corresponding values in the control group. This indicates that the reduction in root size was more pronounced than the reduction in crown size. The premolars in the BMT group exhibited a similar reduction in crown and root size. All developing teeth were affected by multiagent chemotherapy and radiation therapy. The most severe disturbances were found in children treated with TBI/CY at a young age.</description><subject>Age Factors</subject><subject>Antineoplastic Agents, Alkylating - therapeutic use</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Bicuspid - drug effects</subject><subject>Bicuspid - pathology</subject><subject>Bicuspid - radiation effects</subject><subject>Bone Marrow Transplantation</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Cuspid - drug effects</subject><subject>Cuspid - pathology</subject><subject>Cuspid - radiation effects</subject><subject>Cyclophosphamide - therapeutic use</subject><subject>Female</subject><subject>Hematologic Neoplasms - drug therapy</subject><subject>Hematologic Neoplasms - radiotherapy</subject><subject>Humans</subject><subject>Incisor - diagnostic imaging</subject><subject>Incisor - drug effects</subject><subject>Incisor - pathology</subject><subject>Male</subject><subject>Mandible</subject><subject>Medicin och hälsovetenskap</subject><subject>Molar - drug effects</subject><subject>Molar - pathology</subject><subject>Molar - radiation effects</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - radiotherapy</subject><subject>Neoplasms - therapy</subject><subject>Odontogenesis - drug effects</subject><subject>Odontogenesis - radiation effects</subject><subject>Odontometry</subject><subject>Radiography, Panoramic</subject><subject>Tooth Crown - diagnostic imaging</subject><subject>Tooth Crown - drug effects</subject><subject>Tooth Crown - pathology</subject><subject>Tooth Root - drug effects</subject><subject>Tooth Root - pathology</subject><subject>Tooth Root - radiation effects</subject><subject>Whole-Body Irradiation</subject><issn>0141-5387</issn><issn>1460-2210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLAzEUhYMoWqs7t8L8AKfNnWSSzFJEW6FUEEVxE9LkVqedR0nG17832lpXrm5OznduwiHkBOgAaMGGuGiHUAyyAeSwQ3rABU2zDOgu6VHgkOZMyQNyGMKCUsoUl_tkvwDFqOA9Mp20zXPaoa8Th01nqjjesGpXdVRJ2ST2paycxyYx80glnUfT_Xjz1ie1qcrnxkTlyoAm4BHZm5sq4PFm9sn91eXdxTid3IyuL84nqeVcdamUlmeK2kIipdZQm89mUcqZir4xQnCbFc4U6BCMEg7AgRSCcZsrUFayPknXe8M7rl5neuXL2vhP3ZpSb66W8YSaM6lyiLz8l1_51v2FfoNQZKqQeUyerZPWtyF4nG-zQPV3_zr2H2mdafh56HSNx201ui28Kfzv42Xo8GNrG7_UQjKZ6_Hjk55SMR493ErN2BfZnZJz</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>Näsman, Margareta</creator><creator>Forsberg, Carl-Magnus</creator><creator>Dahllöf, Göran</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>19970401</creationdate><title>Long-term dental development in children after treatment for malignant disease</title><author>Näsman, Margareta ; Forsberg, Carl-Magnus ; Dahllöf, Göran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-77c4280c97e00ca0c5bb80c7b8c44aa664c29da9ede1a86d11d176634c5818c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Age Factors</topic><topic>Antineoplastic Agents, Alkylating - therapeutic use</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Bicuspid - drug effects</topic><topic>Bicuspid - pathology</topic><topic>Bicuspid - radiation effects</topic><topic>Bone Marrow Transplantation</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Cuspid - drug effects</topic><topic>Cuspid - pathology</topic><topic>Cuspid - radiation effects</topic><topic>Cyclophosphamide - therapeutic use</topic><topic>Female</topic><topic>Hematologic Neoplasms - drug therapy</topic><topic>Hematologic Neoplasms - radiotherapy</topic><topic>Humans</topic><topic>Incisor - diagnostic imaging</topic><topic>Incisor - drug effects</topic><topic>Incisor - pathology</topic><topic>Male</topic><topic>Mandible</topic><topic>Medicin och hälsovetenskap</topic><topic>Molar - drug effects</topic><topic>Molar - pathology</topic><topic>Molar - radiation effects</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - radiotherapy</topic><topic>Neoplasms - therapy</topic><topic>Odontogenesis - drug effects</topic><topic>Odontogenesis - radiation effects</topic><topic>Odontometry</topic><topic>Radiography, Panoramic</topic><topic>Tooth Crown - diagnostic imaging</topic><topic>Tooth Crown - drug effects</topic><topic>Tooth Crown - pathology</topic><topic>Tooth Root - drug effects</topic><topic>Tooth Root - pathology</topic><topic>Tooth Root - radiation effects</topic><topic>Whole-Body Irradiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Näsman, Margareta</creatorcontrib><creatorcontrib>Forsberg, Carl-Magnus</creatorcontrib><creatorcontrib>Dahllöf, Göran</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>European journal of orthodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Näsman, Margareta</au><au>Forsberg, Carl-Magnus</au><au>Dahllöf, Göran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term dental development in children after treatment for malignant disease</atitle><jtitle>European journal of orthodontics</jtitle><addtitle>European Journal of Orthodontics</addtitle><date>1997-04-01</date><risdate>1997</risdate><volume>19</volume><issue>2</issue><spage>151</spage><epage>159</epage><pages>151-159</pages><issn>0141-5387</issn><eissn>1460-2210</eissn><abstract>A radiographic dental examination was performed in 16 children conditioned with total body irradiation (TBI) and cyclophosphamide (CY) prior to bone marrow transplantation (BMT), and in 52 children treated with multiagent chemotherapy. For each child, three age- and sex-matched healthy controls were selected. Evaluation of disturbances in dental development and tooth size was based on planimetric measurements of mandibular teeth on panoramic radiographs. Short V-shaped roots were diagnosed in 94 per cent of the children treated with TBI/CY compared with 19 per cent in the chemotherapy group (P<0.001). Children receiving TBI/CY also exhibited a pronounced reduction in tooth size compared with the controls. Reductions varied from 19 per cent in incisors to 39 per cent in the second molars. In the chemotherapy group the corresponding values were 7 and 15 per cent respectively. When comparing crown/root ratios, the indices for incisors, canines (P<0.05) and molars (P<0.01) in the BMT group were significantly higher than the corresponding values in the control group. This indicates that the reduction in root size was more pronounced than the reduction in crown size. The premolars in the BMT group exhibited a similar reduction in crown and root size. All developing teeth were affected by multiagent chemotherapy and radiation therapy. The most severe disturbances were found in children treated with TBI/CY at a young age.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>9183064</pmid><doi>10.1093/ejo/19.2.151</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0141-5387 |
| ispartof | European journal of orthodontics, 1997-04, Vol.19 (2), p.151-159 |
| issn | 0141-5387 1460-2210 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Age Factors Antineoplastic Agents, Alkylating - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bicuspid - drug effects Bicuspid - pathology Bicuspid - radiation effects Bone Marrow Transplantation Case-Control Studies Child Cuspid - drug effects Cuspid - pathology Cuspid - radiation effects Cyclophosphamide - therapeutic use Female Hematologic Neoplasms - drug therapy Hematologic Neoplasms - radiotherapy Humans Incisor - diagnostic imaging Incisor - drug effects Incisor - pathology Male Mandible Medicin och hälsovetenskap Molar - drug effects Molar - pathology Molar - radiation effects Neoplasms - drug therapy Neoplasms - radiotherapy Neoplasms - therapy Odontogenesis - drug effects Odontogenesis - radiation effects Odontometry Radiography, Panoramic Tooth Crown - diagnostic imaging Tooth Crown - drug effects Tooth Crown - pathology Tooth Root - drug effects Tooth Root - pathology Tooth Root - radiation effects Whole-Body Irradiation |
| title | Long-term dental development in children after treatment for malignant disease |
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