The Role of Calcium in the Regulation of Apoptosis

Apoptosis (programmed cell death) has gained widespread attention due to its roles in a variety of physiological and pathological processes, yet precisely how apoptosis is regulated by external and internal cues remains unclear. Work from our laboratories and others has implicated alterations in intracellular Ca2+in apoptosis, and more recent work has defined particular biochemical processes that are targeted by Ca2+in apoptotic cells. This review will summarize the role of Ca2+in apoptosis within the context of what is known about the core components of the effector machinery for apoptosis.