Induction of HIV‐1 Specific Mucosal Immune Responses by DNA Vaccination

DNA vaccination has been shown to induce immunity against several different pathogens including HIV‐1. The authors demonstrate here that administration of DNA vaccines via the intranasal route is sufficient to induce immune responses both at distal mucosal sites and systemically. Since transmission...

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Veröffentlicht in:	Scandinavian journal of immunology 1997-10, Vol.46 (4), p.326-330
Hauptverfasser:	ASAKURA, Y., HINKULA, J., LEANDERSSON, A.‐C., FUKUSHIMA, J., OKUDA, K., WAHREN, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal AIDS/HIV Animals Antigens, Viral - immunology Epitopes - immunology HIV Antibodies - biosynthesis HIV-1 - immunology human immunodeficiency virus 1 Immunity, Mucosal Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Inbred DBA Vaccines, DNA - administration & dosage Vaccines, DNA - immunology
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Beschreibung
Zusammenfassung:	DNA vaccination has been shown to induce immunity against several different pathogens including HIV‐1. The authors demonstrate here that administration of DNA vaccines via the intranasal route is sufficient to induce immune responses both at distal mucosal sites and systemically. Since transmission of HIV‐1 occurs largely across mucosal surfaces, the intranasal route provides a further means of application for DNA immunization.
ISSN:	0300-9475 1365-3083
DOI:	10.1046/j.1365-3083.1997.d01-146.x