p53 polymorphism and risk of cervical cancer

Storey and co-workers claim that there is an association between a common variant of the p53 tumour-suppressor gene and the development of invasive cervical carcinoma. Here we present evidence to refute this, based on a reassessment of the importance of the polymorphism at codon 72 in the p53 gene f...

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Veröffentlicht in:	Nature (London) 1998-12, Vol.396 (6711), p.531-531
Hauptverfasser:	Josefsson, Agnetha M, Magnusson, Patrik K. E, Ylitalo, Nathalie, Quarforth-Tubbin, Pernilla, Pontén, Jan, Adami, Hans Olov, Gyllensten, Ulf B
Format:	Artikel
Sprache:	eng
Schlagworte:	Cervical cancer Female Genes, p53 Genetic Predisposition to Disease Genotype Humanities and Social Sciences Humans MEDICIN Medicin och hälsovetenskap MEDICINE multidisciplinary Oncogene Proteins, Viral - metabolism Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomaviridae - physiology Polymerase Chain Reaction Polymorphism, Genetic Repressor Proteins Risk Factors Science Science (multidisciplinary) scientific-correspondence Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Virus Infections - genetics Tumor Virus Infections - virology Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - virology
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Beschreibung
Zusammenfassung:	Storey and co-workers claim that there is an association between a common variant of the p53 tumour-suppressor gene and the development of invasive cervical carcinoma. Here we present evidence to refute this, based on a reassessment of the importance of the polymorphism at codon 72 in the p53 gene for the development of cervical cancer.
ISSN:	0028-0836 1476-4687 1476-4687
DOI:	10.1038/25037