Genome sequencing and conservation genomics in the Scandinavian wolverine population

Genetic approaches have proved valuable to the study and conservation of endangered populations', especially for monitoring programs, and there is potential for further developments in this direction by extending analyses to the genomic level We assembled the genome of the wolverine (Guio gulo), a mustelid that in Scandinavia has recently recovered from a significant population decline, and obtained a 2.42 Gb draft sequence representing >85% of the genome and including >21,000 protein-coding genes. We then performed whole-genome resequencing of 10 Scandinavian wolverinesfor population genomic and demographic analyses. Genetic diversity was among the lowest detected in a red-listed population (mean genome-wide nucleotide diversity of 0.05%). Results of the demographic analyses indicated a long-term decline of the effective population size (Ne) from 10,000 well before the last glaciation to 85% del genoma e incluyó >21, 000 genes codificadores de proteínas. Desp