Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study

Endothelin receptor antagonism produces favorable short-term hemodynamic effects in heart failure, but the clinical effects of longer term therapy have not been evaluated. Three hundred and seventy patients with symptoms of heart failure at rest or on minimal exertion and a left ventricular ejection...

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Veröffentlicht in:	Journal of cardiac failure 2005-02, Vol.11 (1), p.12-20
Hauptverfasser:	Packer, Milton, McMurray, John, Massie, Barry M., Caspi, Abraham, Charlon, Vincent, Cohen-Solal, Alain, Kiowski, Wolfgang, Kostuk, William, Krum, Henry, Levine, Barry, Rizzon, Paolo, Soler, Jordi, Swedberg, Karl, Anderson, Susan, Demets, David L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antihypertensive Agents - administration & dosage Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Antihypertensive Agents/administration & dosage/pharmacology/therapeutic bosentan Cardiology and Cardiovascular Disease clinical trial Congestive/drug therapy/mortality/physiopathology Double-Blind Method endothelin Erythrocyte Count Female Heart Failure Heart Failure - drug therapy Heart Failure - mortality Heart Failure - physiopathology Hemoglobins - analysis Hospitalization Humans Kardiologi och kardiovaskulära sjukdomar Male Middle Aged Sulfonamides - administration & dosage Sulfonamides - pharmacology Sulfonamides - therapeutic use Sulfonamides/administration & dosage/pharmacology/therapeutic use Survival Analysis Treatment Failure use
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Zusammenfassung:	Endothelin receptor antagonism produces favorable short-term hemodynamic effects in heart failure, but the clinical effects of longer term therapy have not been evaluated. Three hundred and seventy patients with symptoms of heart failure at rest or on minimal exertion and a left ventricular ejection fraction
ISSN:	1071-9164 1532-8414
DOI:	10.1016/j.cardfail.2004.05.006