Inclusion body myositis with early onset: a population-based study

Introduction Inclusion body myositis (IBM), an inflammatory myopathy with progressive weakness without efficient treatment, typically presents after 45 years of age and younger patients are sparsely studied. Methods In a population-based study during a 33-year period, 142 patients with IBM were iden...

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Veröffentlicht in:	Journal of neurology 2023-11, Vol.270 (11), p.5483-5492
Hauptverfasser:	Lindgren, Ulrika, Hedberg-Oldfors, Carola, Pullerits, Rille, Lindberg, Christopher, Oldfors, Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Biopsy Comorbidity Cytochrome-c oxidase Diagnosis Epidemiology Inclusion body myositis Inflammation Inflammatory diseases Inflammatory myopathy Medical records Medicine Medicine & Public Health mitochondrial Mitochondrial DNA Muscle strength Muscular weakness Musculoskeletal diseases Mutation Myopathy Myositis Neurologi Neurology Neuroradiology Neurosciences Neurosciences & Neurology Original Communication Patients Population studies Population-based studies Quadriceps muscle Survival
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Beschreibung
Zusammenfassung:	Introduction Inclusion body myositis (IBM), an inflammatory myopathy with progressive weakness without efficient treatment, typically presents after 45 years of age and younger patients are sparsely studied. Methods In a population-based study during a 33-year period, 142 patients with IBM were identified in western Sweden. Six patients fell outside the European Neuromuscular Centre 2011 criteria for IBM due to young age at symptom onset, verified by a muscle biopsy
ISSN:	0340-5354 1432-1459
DOI:	10.1007/s00415-023-11878-w