Dapagliflozin and the Incidence of Type 2 Diabetes in Patients With Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis From DAPA-HF

The sodium-glucose cotransporter 2 inhibitor dapagliflozin reduced the risk of cardiovascular mortality and worsening heart failure in the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure (DAPA-HF) trial. This report explores the effect of dapagliflozin on incident type 2 diabetes (...

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Veröffentlicht in:	Diabetes care 2021-02, Vol.44 (2), p.586-594
Hauptverfasser:	Inzucchi, Silvio E, Docherty, Kieran F, Køber, Lars, Kosiborod, Mikhail N, Martinez, Felipe A, Ponikowski, Piotr, Sabatine, Marc S, Solomon, Scott D, Verma, Subodh, Bělohlávek, Jan, Böhm, Michael, Chiang, Chern-En, de Boer, Rudolf A, Diez, Mirta, Dukát, Andre, Ljungman, Charlotta E A, Bengtsson, Olof, Langkilde, Anna Maria, Sjöstrand, Mikaela, Jhund, Pardeep S, McMurray, John J V
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidiabetics Cardiovascular diseases Clinical trials Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Ejection fraction Endocrinology and Diabetes Endokrinologi och diabetes Hazard assessment Health hazards Health risks Heart diseases Heart failure Mortality Research design Sodium-glucose cotransporter Statistical models Subgroups
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Zusammenfassung:	The sodium-glucose cotransporter 2 inhibitor dapagliflozin reduced the risk of cardiovascular mortality and worsening heart failure in the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure (DAPA-HF) trial. This report explores the effect of dapagliflozin on incident type 2 diabetes (T2D) in the cohort without diabetes enrolled in the trial. The subgroup of 2,605 patients with heart failure and reduced ejection fraction (HFrEF), no prior history of diabetes, and an HbA of
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc20-1675