The molecular anatomy and functions of the choroid plexus in healthy and diseased brain

The choroid plexus (CP) is located in the ventricular system of the brain (one in each ventricle), and the CP epithelial cells form an important barrier between the blood and the cerebrospinal fluid (CSF). Their main function comprises CSF secretion, maintenance of brain homeostasis, signalling, and forming a neuroprotective barrier against harmful external and internal compounds. The CPs mature early and demonstrate expressional changes of barrier-specific genes and proteins related to location and developmental stage of the CP. Important proteins for the barrier function include tight junction proteins, numerous transporters and enzymes. Natural senescence leads to structural changes in the CP cells and reduced or loss of function, while further loss of CP function and changes in immune status may be relevant in neurodegenerative diseases such as Alzheimer's disease and Multiple Sclerosis. Neuroprotective genes expressed at CPs may be unexplored targets for new therapies for neurodegenerative diseases. •Choroid plexuses (CPs) make up the Blood-CSF barrier.•CP functions include CSF secretion and maintenance of brain homeostasis.•CP shows developmental and regional changes of barrier-specific gene expression.•Tight junctions, transporters and enzymes contribute to a complex barrier system.•CP functions in development, aging and neurodegenerative diseases (AD, MS).