Age of recipient and number of doses differentially impact human B and T cell immune memory responses to HPV vaccination

Highlights ► Measured B and T cell memory of girls and women after 2 or 3 doses of HPV vaccine. ► Both dose and age impacted B cell immune memory response. ► Dose, but not age, impacted T cell memory response; 3 doses led to higher response.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2012-05, Vol.30 (24), p.3572-3579
Hauptverfasser:	Smolen, Kinga K, Gelinas, Laura, Franzen, Lisa, Dobson, Simon, Dawar, Meena, Ogilvie, Gina, Krajden, Mel, Fortuno, Edgardo S, Kollmann, Tobias R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Age Factors Allergy and Immunology anthropogenic activities B-lymphocytes B-Lymphocytes - immunology Cervical cancer Child Cohort Studies Data processing Dose ELISPOT Female girls Human papilloma virus Human papillomavirus Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 Humans Immune memory Immunologi immunologic memory Immunological memory Immunology Longitudinal Studies Lymphocytes B Lymphocytes T Medical research Memory cells Papillomavirus Infections - immunology Papillomavirus Infections - prevention & control Papillomavirus Vaccines - administration & dosage Papillomavirus Vaccines - immunology T-lymphocytes T-Lymphocytes - immunology vaccination Vaccination - methods Vaccine vaccine development Vaccines women Young Adult
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Beschreibung
Zusammenfassung:	Highlights ► Measured B and T cell memory of girls and women after 2 or 3 doses of HPV vaccine. ► Both dose and age impacted B cell immune memory response. ► Dose, but not age, impacted T cell memory response; 3 doses led to higher response.
ISSN:	0264-410X 1873-2518 1873-2518
DOI:	10.1016/j.vaccine.2012.03.051