Gammahydroxybutyric acid: Central biochemical and behavioral effects in neonatal rats

Administration of gammahydroxybutyric acid (GHBA) to 4 days old animals caused a dose dependent decrease in locomotor activity. GHBA also induced a marked hypoventilation, irregular breathing and finally apnea, while heart rate was slightly increased. Changes in monoamine neurotransmitter turnover i...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1985, Vol.23 (2), p.185-189
Hauptverfasser:	Hedner, Thomas, Hedner, Jan, Iversen, Knut, Wessberg, Per, Lundborg, Per
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn - physiology Biogenic Amines Biogenic Amines - metabolism Biological and medical sciences Brain Brain - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors CNS drug effects Farmakologi och toxikologi Female Fundamental and applied biological sciences. Psychology GHBA Heart Rate Heart Rate - drug effects Hydroxybutyrates Hydroxybutyrates - pharmacology Inbred Strains metabolism Motor Activity Motor Activity - drug effects Neonate Newborn pharmacology Pharmacology and Toxicology physiology Pregnancy Rats Rats, Inbred Strains Respiration Respiration - drug effects Sodium Oxybate Sodium Oxybate - metabolism Sodium Oxybate - pharmacology Synaptic Transmission Synaptic Transmission - drug effects Time Factors Vertebrates: nervous system and sense organs
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Zusammenfassung:	Administration of gammahydroxybutyric acid (GHBA) to 4 days old animals caused a dose dependent decrease in locomotor activity. GHBA also induced a marked hypoventilation, irregular breathing and finally apnea, while heart rate was slightly increased. Changes in monoamine neurotransmitter turnover indicated an inhibition of dopamine (DA) neurotransmission. It is concluded that GHBA mechanisms in the neonatal rat brain are biochemically as well as functionally mature at an early age and that the effects on locomotor activity and respiratory regulation at least partly may involve interactions with central DA neurotransmission.
ISSN:	0091-3057 1873-5177
DOI:	10.1016/0091-3057(85)90553-2