Sympathetic Response and Outcomes Following Renal Denervation in Patients with Chronic Heart Failure: 12-Month Outcomes From the SYMPLICITY HF Feasibility Study

Highlights • RDN was associated with reductions in NT-proBNP and the 120-minute glucose tolerance test in HF patients with renal dysfunction 12 months after treatment. • No deterioration in other indices of cardiac and renal function 12 months after RDN treatment was observed. • No serious adverse e...

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Veröffentlicht in:	Journal of cardiac failure 2017-09, Vol.23 (9), p.702-707
Hauptverfasser:	Hopper, Ingrid, MBBS, PhD, Gronda, Edoardo, MD, Hoppe, Uta C., MD, Rundqvist, Bengt, MD, PhD, Marwick, Thomas H., MBBS, PhD, MPh, Shetty, Sharad, MD, Hayward, Christopher, MD, Lambert, Thomas, MD, Hering, Dagmara, MD, PhD, Esler, Murray, MBBS, PhD, Schlaich, Markus, MD, Walton, Antony, MBBS, Airoldi, Flavio, MD, Brandt, Mathias-Christoph, MD, Cohen, Sidney A., MD, PhD, Reiters, Pascalle, MSc, Krum, Henry, MBBS PhD, (deceased)
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Cardiac and Cardiovascular Systems Cardiovascular Cardiovascular System & Cardiology catheter chronic kidney disease Feasibility Studies Female Follow-Up Studies Heart Failure - blood Heart Failure - diagnostic imaging Heart Failure - surgery Humans hypertension Kardiologi Kidney - diagnostic imaging Kidney - innervation left-ventricular hypertrophy Male Middle Aged pilot Prospective Studies randomized controlled-trial renal impairment resistant safety Sympathectomy - methods Sympathectomy - trends Sympathetic nervous system systolic function Time Factors Treatment Outcome
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Beschreibung
Zusammenfassung:	Highlights • RDN was associated with reductions in NT-proBNP and the 120-minute glucose tolerance test in HF patients with renal dysfunction 12 months after treatment. • No deterioration in other indices of cardiac and renal function 12 months after RDN treatment was observed. • No serious adverse events were adjudicated as related to the device, procedure, or therapy. There was one renal artery occlusion that was possibly related to the denervation procedure.
ISSN:	1071-9164 1532-8414
DOI:	10.1016/j.cardfail.2017.06.004