Serum concentrations of the axonal injury marker neurofilament light protein are not influenced by blood-brain barrier permeability

Highlights • Serum NFL increases following both cranial irradiation (CIR) and anesthesia in mice. • Serum NFL does not correlate with opening of the blood-brain barrier after CIR. • In humans, the levels of NFL in serum mirror the levels in cerebrospinal fluid.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2017-08, Vol.1668, p.12-19
Hauptverfasser:	Kalm, Marie, Boström, Martina, Sandelius, Åsa, Eriksson, Yohanna, Ek, C. Joakim, Blennow, Kaj, Björk-Eriksson, Thomas, Zetterberg, Henrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - metabolism Biomarker biomarkers Biomarkers - blood Blood-Brain Barrier - metabolism Brain Injuries - metabolism Cancer and Oncology Cancer och onkologi chain childhood children Cranial radiotherapy Disease Progression Female inflammation integrity irradiation Juvenile brain Late effects mice Mice, Inbred C57BL Neurofilament Proteins - blood Neurology Neurons - metabolism Neurosciences & Neurology Neurotoxicity Permeability progression tumors
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Beschreibung
Zusammenfassung:	Highlights • Serum NFL increases following both cranial irradiation (CIR) and anesthesia in mice. • Serum NFL does not correlate with opening of the blood-brain barrier after CIR. • In humans, the levels of NFL in serum mirror the levels in cerebrospinal fluid.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2017.05.011