TIA model is attainable in Wistar rats by intraluminal occlusion of the MCA for 10 min or shorter

TIA model is attainable in Wistar rats by intraluminal occlusion of the MCA for 10 min or shorter

Highlights • Experimental studies on TIA are scarce. • We developed a clinically relevant TIA model for Wistar rats. • 10 min or shorter intraluminal middle cerebral artery occlusion resumes in TIA. • This model leads to no neurological deficit or MRI lesion at 24 h. • But it is associated with some...

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Veröffentlicht in:Brain research 2017-05, Vol.1663, p.166-173
Hauptverfasser: Durukan Tolvanen, A, Tatlisumak, E, Pedrono, E, Abo-Ramadan, U, Tatlisumak, T
Format: Artikel
Sprache:eng
Schlagworte:
Animal model
artery occlusion
attack
brain
Cerebral ischemia
delayed
focal cerebral-ischemia
infarction
Magnetic resonance imaging
Middle cerebral artery
Neurology
neuronal death
Neurosciences
Neurovetenskaper
Rat
receptor antagonist
stroke
tolerance
Transient
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Beschreibung
Zusammenfassung:Highlights • Experimental studies on TIA are scarce. • We developed a clinically relevant TIA model for Wistar rats. • 10 min or shorter intraluminal middle cerebral artery occlusion resumes in TIA. • This model leads to no neurological deficit or MRI lesion at 24 h. • But it is associated with some apoptosis and neuronal necrosis.
ISSN:0006-8993
DOI:10.1016/j.brainres.2017.03.010