Increased basal ganglia binding of (18) F-AV-1451 in patients with progressive supranuclear palsy

Increased basal ganglia binding of (18) F-AV-1451 in patients with progressive supranuclear palsy

Progressive supranuclear palsy (PSP) is difficult to diagnose accurately. The recently developed tau PET tracers may improve the diagnostic work-up of PSP.Regional tau accumulation was studied using (18) F-AV-1451 PET in 11 patients with PSP and 11 age-matched healthy controls in the Swedish BioFind...

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Veröffentlicht in:Movement disorders 2017, Vol.32 (1), p.108
Hauptverfasser: Smith, Ruben, Schain, Martin, Nilsson, Christer, Strandberg, Olof, Olsson, Tomas, Hägerström, Douglas, Jögi, Jonas, Borroni, Edilio, Schöll, Michael, Honer, Michael, Hansson, Oskar
Format: Artikel
Sprache:eng
Schlagworte:
Clinical Medicine
Klinisk medicin
Medical Biotechnology
Medicinsk bioteknologi
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Zusammenfassung:Progressive supranuclear palsy (PSP) is difficult to diagnose accurately. The recently developed tau PET tracers may improve the diagnostic work-up of PSP.Regional tau accumulation was studied using (18) F-AV-1451 PET in 11 patients with PSP and 11 age-matched healthy controls in the Swedish BioFinder study.(18) F-AV-1451 standard uptake volume ratios were significantly higher in the basal ganglia in PSP patients when compared with controls (globus pallidus 1.75 vs 1.50; putamen 1.51 vs 1.35). Retention in the basal ganglia was correlated with age in both groups (r=.43-.78, P
ISSN:1531-8257
DOI:10.1002/mds.26813