Multigrowth Factor Delivery via Immobilization of Gene Therapy Vectors

Molecules can be immobilized onto biomaterials by a chemical vapor deposition (CVD) coating strategy. Pentafluorophenolester groups react with amine side chains on antibodies, which can selectively immobilize adenoviral vectors for gene delivery of growth factors. These vectors can produce functiona...

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Veröffentlicht in:	Advanced materials (Weinheim) 2016-04, Vol.28 (16), p.3145-3151
Hauptverfasser:	Hao, Jie, Cheng, Kenneth C. K., Kruger, Laura G., Larsson, Lena, Sugai, James V., Lahann, Joerg, Giannobile, William V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - immunology Antibodies, Immobilized - chemistry Biocompatible Materials - chemistry Biomaterials Biomedical materials bone morphogenetic protein-7 bone morphogenetic proteins Cells, Cultured Chemical vapor deposition Chemistry Clinical Medicine defects differentiation drug delivery Gene therapy gene transfer Gene Transfer Techniques Genetic Therapy - methods Genetic Vectors - genetics Genetic Vectors - immunology Humans in-vitro Intercellular Signaling Peptides and Proteins - biosynthesis Intercellular Signaling Peptides and Proteins - genetics Klinisk medicin ligament Materials Science Materials selection Mathematical analysis microparticles osseointegration Periodontal Ligament - cytology Physics platelet-derived growth factor regeneration regenerative medicine Regenerative Medicine - methods scaffolds Science & Technology - Other Topics Surgical implants tissue regeneration Vectors (mathematics) vivo Wound Healing
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Beschreibung
Zusammenfassung:	Molecules can be immobilized onto biomaterials by a chemical vapor deposition (CVD) coating strategy. Pentafluorophenolester groups react with amine side chains on antibodies, which can selectively immobilize adenoviral vectors for gene delivery of growth factors. These vectors can produce functional proteins within defined regions of biomaterials to produce customizable structures for targeted tissue regeneration.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201600027