Drug the Bug

Microbial metabolism of dietary components has been causally linked to cardiovascular disease and atherosclerosis. Now, Wang et al. demonstrate that inhibition of microbial TMA lyases, essential for production of pro-atherogenic trimethylamines, prevents atherosclerosis in vivo. Microbial metabolism...

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Veröffentlicht in:	Cell 2015-12, Vol.163 (7), p.1565-1566
Hauptverfasser:	Jonsson, Annika Lindskog, Bäckhed, Fredrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis - drug therapy Choline - analogs & derivatives Clinical Medicine Gastrointestinal Tract - microbiology Hexanols - administration & dosage Humans Klinisk medicin Lyases - antagonists & inhibitors Methylamines - metabolism
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Beschreibung
Zusammenfassung:	Microbial metabolism of dietary components has been causally linked to cardiovascular disease and atherosclerosis. Now, Wang et al. demonstrate that inhibition of microbial TMA lyases, essential for production of pro-atherogenic trimethylamines, prevents atherosclerosis in vivo. Microbial metabolism of dietary components has been causally linked to cardiovascular disease and atherosclerosis. Now, Wang et al. demonstrate that inhibition of microbial TMA lyases, essential for production of pro-atherogenic trimethylamines, prevents atherosclerosis in vivo.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2015.12.005