$Neuropsychological Outcome of Children Treated for Standard Risk Medulloblastoma in the PNET4 European Randomized Controlled Trial of Hyperfractionated Versus Standard Radiation Therapy and Maintenance Chemotherapy$

Neuropsychological Outcome of Children Treated for Standard Risk Medulloblastoma in the PNET4 European Randomized Controlled Trial of Hyperfractionated Versus Standard Radiation Therapy and Maintenance Chemotherapy

Purpose In the European HIT-SIOP PNET4 randomized controlled trial, children with standard risk medulloblastoma were allocated to hyperfractionated radiation therapy (HFRT arm, including a partially focused boost) or standard radiation therapy (STRT arm), followed, in both arms, by maintenance chemo...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2015-08, Vol.92 (5), p.978-985
Hauptverfasser:	Câmara-Costa, Hugo, PhD, Resch, Anika, MSc, Kieffer, Virginie, MSc, Lalande, Clémence, MSc, Poggi, Geraldina, MD, Kennedy, Colin, MBBS, MD, Bull, Kim, PhD, Calaminus, Gabriele, MD, Grill, Jacques, MD, PhD, Doz, François, MD, Rutkowski, Stefan, MD, Massimino, Maura, MD, Kortmann, Rolf-Dieter, MD, Lannering, Birgitta, MD, Dellatolas, Georges, MD, PhD, Chevignard, Mathilde, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Factors Analysis of Variance Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cerebellar Neoplasms - drug therapy Cerebellar Neoplasms - psychology Cerebellar Neoplasms - radiotherapy CHEMOTHERAPY Child Child, Preschool CHILDREN Cisplatin - administration & dosage Cognition - drug effects Cognition - physiology Cognition - radiation effects Cognition Disorders Cognitive science Confidence Intervals Craniospinal Irradiation - methods DIAGNOSIS Dose Fractionation Europe Executive Function - physiology Executive Function - radiation effects Female GROWTH HAZARDS Hematology, Oncology and Palliative Medicine Humans Intelligence - physiology Intelligence - radiation effects Intelligence Tests Lomustine - administration & dosage Maintenance Chemotherapy - methods Male Medulloblastoma - drug therapy Medulloblastoma - psychology Medulloblastoma - radiotherapy Memory - physiology Memory - radiation effects Neurologi Neurology PATIENTS Pediatrics Pediatrik Prospective Studies Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Regression Analysis Vincristine - administration & dosage Young Adult
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Zusammenfassung:	Purpose In the European HIT-SIOP PNET4 randomized controlled trial, children with standard risk medulloblastoma were allocated to hyperfractionated radiation therapy (HFRT arm, including a partially focused boost) or standard radiation therapy (STRT arm), followed, in both arms, by maintenance chemotherapy. Event-free survival was similar in both arms. Previous work showed that the HFRT arm was associated with worse growth and better questionnaire-based executive function, especially in children
ISSN:	0360-3016 1879-355X 1879-355X
DOI:	10.1016/j.ijrobp.2015.04.023