Insulin resistance and impaired adipogenesis

Highlights • Subcutaneous adipose tissue has a finite expansion capacity. • Adipose cell expansion (hypertrophic obesity) is associated with abdominal obesity and insulin resistance. • The ability to increase subcutaneous adipogenesis is protective. • BMP4 regulates both white and beige/brown subcut...

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Veröffentlicht in:	Trends in endocrinology and metabolism 2015-04, Vol.26 (4), p.193-200
Hauptverfasser:	Gustafson, Birgit, Hedjazifar, Shahram, Gogg, Silvia, Hammarstedt, Ann, Smith, Ulf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipogenesis Adipose Tissue, Brown - immunology Adipose Tissue, Brown - metabolism Adipose Tissue, Brown - pathology Adiposity Animals BMP4 Cell and Molecular Biology Cell- och molekylärbiologi Down-Regulation Endocrinology & Metabolism Glucose Transporter Type 4 - genetics Glucose Transporter Type 4 - metabolism Gremlin1 Humans Hypertrophy Insulin Resistance Lipid Metabolism Metabolic Syndrome - genetics Metabolic Syndrome - immunology Metabolic Syndrome - metabolism Metabolic Syndrome - pathology Models, Biological obesity Organ Specificity Subcutaneous Fat, Abdominal - immunology Subcutaneous Fat, Abdominal - metabolism Subcutaneous Fat, Abdominal - pathology type 2 diabetes
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Beschreibung
Zusammenfassung:	Highlights • Subcutaneous adipose tissue has a finite expansion capacity. • Adipose cell expansion (hypertrophic obesity) is associated with abdominal obesity and insulin resistance. • The ability to increase subcutaneous adipogenesis is protective. • BMP4 regulates both white and beige/brown subcutaneous adipogenesis.
ISSN:	1043-2760 1879-3061
DOI:	10.1016/j.tem.2015.01.006