The unsaponifiable fraction of extra virgin olive oil promotes apoptosis and attenuates activation and homing properties of T cells from patients with inflammatory bowel disease
•Olive oil unsaponifiable fraction exerts an anti-inflammatory role in IBD patients.•The fraction promotes apoptosis of T cells isolated from IBD patients.•Intestinal and blood T cell activation was attenuated.•The gut homing properties of T cells in patients with IBD were down-regulated.•This fract...
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Veröffentlicht in: | Food chemistry 2014-10, Vol.161, p.353-360 |
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Sprache: | eng |
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Zusammenfassung: | •Olive oil unsaponifiable fraction exerts an anti-inflammatory role in IBD patients.•The fraction promotes apoptosis of T cells isolated from IBD patients.•Intestinal and blood T cell activation was attenuated.•The gut homing properties of T cells in patients with IBD were down-regulated.•This fraction might therefore be considered as a dietary complement in IBD therapy.
The unsaponifiable fraction (UF) of extra virgin olive oil (EVOO) possesses anti-inflammatory properties and exerts preventative effects in murine models of inflammatory bowel disease (IBD). The present study was designed to determine the in vitro effects of UF on blood and intestinal T cells from IBD patients and healthy subjects. The T cell phenotype was investigated by flow cytometry and cytokine secretion was determined by ELISA. The presence of UF of EVOO promoted apoptosis and attenuated activation of intestinal and blood T cells isolated from IBD patients, decreasing the frequency of CD69+ and CD25+ T cells and, also, the secretion of IFN-γ. Moreover, UF reduced the expression of the gut homing receptor integrin β7 on blood T cells from IBD patients. In conclusion, UF modulates the activity and the gut homing capacity of T cells, and might therefore be considered as a dietary complement with an anti-inflammatory role in IBD patients. |
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ISSN: | 0308-8146 1873-7072 |
DOI: | 10.1016/j.foodchem.2014.04.016 |