Clinical Course of Patients With Hyponatremia and Decompensated Systolic Heart Failure and the Effect of Vasopressin Receptor Antagonism With Tolvaptan

Abstract Background Patients with decompensated heart failure, volume overload, and hyponatremia are challenging to manage. Relatively little has been documented regarding the clinical course of these patients during standard in-hospital management or with vasopressin antagonism. Methods and Results...

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Veröffentlicht in:	Journal of cardiac failure 2013-06, Vol.19 (6), p.390-397
Hauptverfasser:	Hauptman, Paul J., MD, Burnett, John, MD, Gheorghiade, Mihai, MD, Grinfeld, Liliana, MD, Konstam, Marvin A., MD, Kostic, Dusan, MD, Krasa, Holly B., MS, Maggioni, Aldo, MD, Ouyang, John, PhD, Swedberg, Karl, MD, Zannad, Faiez, MD, PhD, Zimmer, Chris, MD, Udelson, James E., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis of Variance Antidiuretic Hormone Receptor Antagonists Arginine Vasopressin - blood Benzazepines - therapeutic use Cardiovascular Clinical Medicine Diuretics - therapeutic use Dyspnea - drug therapy Dyspnea - etiology Female Furosemide - therapeutic use Heart failure Heart Failure, Systolic - complications Heart Failure, Systolic - drug therapy Heart Failure, Systolic - mortality Humans hyponatremia Hyponatremia - complications Hyponatremia - drug therapy Klinisk medicin Male Middle Aged prognosis Proportional Hazards Models vasopressin antagonist Weight Loss - drug effects
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Zusammenfassung:	Abstract Background Patients with decompensated heart failure, volume overload, and hyponatremia are challenging to manage. Relatively little has been documented regarding the clinical course of these patients during standard in-hospital management or with vasopressin antagonism. Methods and Results The Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan database was examined to assess the short-term clinical course of patients hospitalized with heart failure and hyponatremia and the effect of tolvaptan on outcomes. In the placebo group, patients with hyponatremia (serum Na+
ISSN:	1071-9164 1532-8414 1532-8414
DOI:	10.1016/j.cardfail.2013.04.001