Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1

Highlight ► Cancer-induced anorexia is attenuated and reversed by cyclooxygenase inhibition, and is dependent on COX-1, but not COX-2 or induced PGE2 expression.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2013-03, Vol.29, p.124-135
Hauptverfasser:	Ruud, Johan, Nilsson, Anna, Engström Ruud, Linda, Wang, Wenhua, Nilsberth, Camilla, Iresjö, Britt-Marie, Lundholm, Kent, Engblom, David, Blomqvist, Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals anorexia Anorexia - drug therapy Anorexia - enzymology Anorexia - etiology Antibodies Appetite Basic Medicine Blood vessels Body Temperature - physiology Body weight loss Cancer Cancer anorexia-cachexia Cerebrospinal fluid Cyclooxygenase Cyclooxygenase 1 - biosynthesis Cyclooxygenase 1 - genetics Cyclooxygenase 2 - physiology Cyclooxygenase Inhibitors - pharmacology Cyclooxygenase-1 Cyclooxygenase-2 Dinoprostone - blood Dinoprostone - cerebrospinal fluid DNA, Complementary - biosynthesis DNA, Complementary - genetics Eating - drug effects Eating - physiology Female Food intake Immunohistochemistry Intramolecular Oxidoreductases - biosynthesis Male Meal pattern MEDICIN MEDICINE Medicinska och farmaceutiska grundvetenskaper Mice Microsomal prostaglandin E synthase-1 Neoplasms, Experimental - complications Neoplasms, Experimental - enzymology Neoplasms, Experimental - psychology Nervous system Prostaglandin E Prostaglandin E2 Prostaglandin-E synthase Prostaglandin-E Synthases Psychiatry Real-Time Polymerase Chain Reaction Receptors, Prostaglandin E, EP4 Subtype - drug effects Receptors, Prostaglandin E, EP4 Subtype - metabolism RNA - biosynthesis RNA - isolation & purification Signal Transduction - drug effects Signal Transduction - physiology Tumorigenesis
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Beschreibung
Zusammenfassung:	Highlight ► Cancer-induced anorexia is attenuated and reversed by cyclooxygenase inhibition, and is dependent on COX-1, but not COX-2 or induced PGE2 expression.
ISSN:	0889-1591 1090-2139 1090-2139
DOI:	10.1016/j.bbi.2012.12.020