First report on fertility after allogeneic uterus transplantation

Abstract Uterus transplantation may become the first available treatment for uterine factor infertility, which is due to the absence or malfunction of the uterus. Here we describe for the first time pregnancy after allogeneic uterus transplantation, as a proof of concept of uterine function in a tra...

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Veröffentlicht in:	Acta obstetricia et gynecologica Scandinavica 2010-11, Vol.89 (11), p.1491-1494
Hauptverfasser:	Díaz-García, César, Akhi, Shamima N., Wallin, Ann, Pellicer, Antonio, Brännström, Mats
Format:	Artikel
Sprache:	eng
Schlagworte:	Allogeneic Animals Biological and medical sciences Birth control Female Fertility Graft Rejection Graft Rejection - prevention & control Gynecology. Andrology. Obstetrics Homologous Immunosuppressive Agents Immunosuppressive Agents - pharmacology Inbred Lew Infertility Infertility, Female - therapy Male Medical sciences Obstetrics, Gynecology and Reproductive Medicine pharmacology Pregnancy prevention & control Rats Rats, Inbred Lew Rats, Sprague-Dawley Reproduktionsmedicin och gynekologi Sprague-Dawley Sterility. Assisted procreation Tacrolimus Tacrolimus - pharmacology therapy Transplantation Transplantation, Homologous Uterus Uterus - transplantation
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Beschreibung
Zusammenfassung:	Abstract Uterus transplantation may become the first available treatment for uterine factor infertility, which is due to the absence or malfunction of the uterus. Here we describe for the first time pregnancy after allogeneic uterus transplantation, as a proof of concept of uterine function in a transplanted uterus in a standardized animal model (rat) under immunosuppression.
ISSN:	0001-6349 1600-0412 1600-0412
DOI:	10.3109/00016349.2010.520688