Nonresponder Patients with Hepatitis C Virus Genotype 2/3 Infection: A Question of Low Systemic Interferon Concentrations?

Twelve of 303 per-protocol patients were nonresponders in a 12-week versus 24-week treatment study of hepatitis C virus (HCV) genotype 2/3 infection. The nonresponders had significantly lower interferon concentrations, as well as significantly greater mean age, body mass index, and viral load. Subop...

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Veröffentlicht in:	Clinical infectious diseases 2010-02, Vol.50 (4), p.e22-e25
Hauptverfasser:	Alsiö, Åsa, Christensen, Peer Brehm, Färkkilä, Martti, Langeland, Nina, Buhl, Mads Rauning, Pedersen, Court, Mørch, Kristine, Haagmans, Bart L., Westin, Johan, Hellstrand, Kristoffer, Norkrans, Gunnar, Lagging, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	administration & dosage Adult Age Factors analysis Antibodies Antibodies - blood Antiviral Agents Antiviral Agents - administration & dosage blood Body Mass Index Combination Drug Therapy Drug Therapy, Combination genetics Hepacivirus Hepacivirus - genetics Hepatitis C Hepatitis C - blood Hepatitis C - drug therapy Hepatitis C - immunology Hepatitis C - virology Hepatitis C virus Humans immunology Interferon Alfa-2a Interferon-alpha - administration & dosage Interferon-alpha - blood Interferon-alpha - immunology Microbiology in the medical area Middle Aged Mikrobiologi inom det medicinska området Multivariate Analysis Polyethylene Glycols Polyethylene Glycols - administration & dosage Recombinant Proteins Ribavirin Ribavirin - administration & dosage RNA RNA, Viral - analysis Viral Viral Load virology
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Zusammenfassung:	Twelve of 303 per-protocol patients were nonresponders in a 12-week versus 24-week treatment study of hepatitis C virus (HCV) genotype 2/3 infection. The nonresponders had significantly lower interferon concentrations, as well as significantly greater mean age, body mass index, and viral load. Suboptimal drug concentrations may thus contribute to lack of response to therapy in patients with infection due to HCV genotype 2/3.
ISSN:	1058-4838 1537-6591 1537-6591
DOI:	10.1086/650006