Gene expression profiling identifies STAT3 as a novel pathway for immunomodulation by cholera toxin adjuvant

Earlier studies have reported on both proinflammatory and anti-inflammatory activities of cholera toxin (CT). As CT is a powerful adjuvant, we were interested in identifying genes with a possible involvement in these functions. A global gene expression analysis in mouse B cells showed that CT regula...

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Veröffentlicht in:	Mucosal immunology 2010-07, Vol.3 (4), p.374-386
Hauptverfasser:	Sjöblom-Hallén, A, Marklund, U, Nerstedt, A, Schön, K, Ekman, L, Bergqvist, P, Löwenadler, B, Lycke, N Y
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/24/590/2291 631/326/41/1319 631/337 Adjuvants, Immunologic - pharmacology Allergology Animals Antibodies B-Lymphocytes - drug effects B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - pathology Biomedical and Life Sciences Biomedicine Cell Line, Tumor Cell Proliferation - drug effects Cholera Toxin - pharmacology Cytokines - immunology Cytokines - metabolism Gastroenterology Gene Expression Profiling Immunoglobulins - biosynthesis Immunoglobulins - genetics Immunology Immunomodulation Lymphocyte Activation - drug effects Mice Mice, Inbred C57BL Mice, Nude Microbiology in the Medical Area Mikrobiologi inom det medicinska området Signal Transduction - drug effects Signal Transduction - immunology Spleen - pathology STAT3 Transcription Factor - genetics STAT3 Transcription Factor - immunology STAT3 Transcription Factor - metabolism
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Beschreibung
Zusammenfassung:	Earlier studies have reported on both proinflammatory and anti-inflammatory activities of cholera toxin (CT). As CT is a powerful adjuvant, we were interested in identifying genes with a possible involvement in these functions. A global gene expression analysis in mouse B cells showed that CT regulated
ISSN:	1933-0219 1935-3456 1935-3456
DOI:	10.1038/mi.2010.16