White matter hyperintensities and depression—preliminary results from the LADIS study

Background White matter hyperintensities have been associated with the development of depression in older subjects, though the details of this relationship are not fully understood. Methods In a pan‐European multicentre study of 629 older subjects, we examined the relationship between MRI white matt...

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Veröffentlicht in:	International journal of geriatric psychiatry 2005-07, Vol.20 (7), p.674-679
Hauptverfasser:	Firbank, Michael J., O'Brien, John T., Pakrasi, Sanjeet, Pantoni, Leonardo, Simoni, Michela, Erkinjuntti, Timo, Wallin, Anders, Wahlund, Lars‐Olof, Straaten, Ilse van, Inzitari, Domenico
Format:	Artikel
Sprache:	eng
Schlagworte:	80 and over Aged Aged, 80 and over Brain Brain - pathology Depression Depression - pathology Depressive Disorder Depressive Disorder - pathology elderly Female Geriatric Assessment Geriatric psychiatry Humans Hypertension Hypertension - pathology Hypertension - psychology Magnetic Resonance Imaging Magnetic Resonance Imaging - methods Male MEDICAL AND HEALTH SCIENCES MEDICIN OCH HÄLSOVETENSKAP Mental depression methods MRI Neurology NMR Nuclear magnetic resonance Older people pathology Psychiatric Status Rating Scales psychology Quality of Life Stroke Stroke - pathology Stroke - psychology White matter hyperintensities
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Zusammenfassung:	Background White matter hyperintensities have been associated with the development of depression in older subjects, though the details of this relationship are not fully understood. Methods In a pan‐European multicentre study of 629 older subjects, we examined the relationship between MRI white matter hyperintensities (WMH), depressive symptoms and self perceived health quality of life (QOL). WMH were rated using a three‐point scale. Results We found depressive symptoms as assessed by the geriatric depression 15‐item scale to be associated with WMH rating (Spearman's rho 0.11, p = 0.008) and also with the Euro‐QOL health score (Spearman's rho −0.5, p
ISSN:	0885-6230 1099-1166
DOI:	10.1002/gps.1342