Association of type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population

Involvement of cyclooxygenase (COX)-mediated inflammation in type 2 diabetes has not been studied, and the association between cytokine-mediated inflammation and diabetes is not fully clarified. 15-Keto-dihydro-prostaglandin F2alpha (a metabolite of prostaglandin F2alpha and an indicator of COX-medi...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2004-04, Vol.109 (14), p.1729-1734
Hauptverfasser:	HELMERSSON, Johanna, VESSBY, Bengt, LARSSON, Anders, BASU, Samar
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged alpha-Tocopherol - blood Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Aspirin - therapeutic use Biological and medical sciences Biological Markers Biomarkers Blood and lymphatic vessels Blood Glucose - analysis Body Mass Index C-Reactive Protein - analysis Cardiology. Vascular system Cohort Studies Comorbidity Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - metabolism Dinoprost - analogs & derivatives Dinoprost - urine Dinoprost/analogs & derivatives/urine Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Follow-Up Studies Humans Inflammation Insulin - blood Lipids - blood Male Medical sciences MEDICIN MEDICINE Oxidative Stress Prostaglandin-Endoperoxide Synthases - physiology Serum Amyloid A Protein - analysis Sweden - epidemiology
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Zusammenfassung:	Involvement of cyclooxygenase (COX)-mediated inflammation in type 2 diabetes has not been studied, and the association between cytokine-mediated inflammation and diabetes is not fully clarified. 15-Keto-dihydro-prostaglandin F2alpha (a metabolite of prostaglandin F2alpha and an indicator of COX-mediated inflammation), high-sensitivity C-reactive protein (CRP), serum amyloid protein A (SAA), 8-iso-PGF2alpha (a nonenzymatic, free radical product of arachidonic acid and an indicator of oxidative stress), and alpha-tocopherol were measured in a population-based sample of 77-year-old men (n=765), in which 112 men had type 2 diabetes. The inflammatory indicators were increased in men with diabetes (urinary 15-keto-dihydro-PGF2alpha, P
ISSN:	0009-7322 1524-4539 1524-4539
DOI:	10.1161/01.CIR.0000124718.99562.91