Detection of point mutations in rpoB gene of rifampin-resistant Rickettsia typhi

The rpoB gene of rifampin-resistant Rickettsia typhi (Rif mutant) and wild-type R. typhi were sequenced and compared. The Rif mutant rpoB had three nucleotide substitutions, which resulted in amino acid changes at residues 151, 201, and 271 and may be the basis for the rifampin resistance.

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Bibliographische Detailangaben
Veröffentlicht in:	Antimicrobial agents and chemotherapy 1998-07, Vol.42 (7), p.1845-1846
Hauptverfasser:	TROYER, J. M, RADULOVIC, S, ANDERSSON, S. G. E, AZAD, A. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences DNA-Directed RNA Polymerases - genetics Drug Resistance, Microbial - genetics Genes, Bacterial Mechanisms of Resistance Medical sciences Molecular Sequence Data Pharmacology. Drug treatments Point Mutation Rickettsia typhi - drug effects Rickettsia typhi - genetics Rifampin - pharmacology
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Beschreibung
Zusammenfassung:	The rpoB gene of rifampin-resistant Rickettsia typhi (Rif mutant) and wild-type R. typhi were sequenced and compared. The Rif mutant rpoB had three nucleotide substitutions, which resulted in amino acid changes at residues 151, 201, and 271 and may be the basis for the rifampin resistance.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.42.7.1845