Electrochemical detection of disodium 3,3′-azobis-(6-hydroxy-) benzoate (olsalazine sodium)

Electrochemical detection of disodium 3,3′‐azobis‐(6‐hydroxy‐)benzoate, olsalazine sodium, in reversed phase liquid chromatography is shown to provide a detection limit of 40 fmol and a linear range extending up to 4 nmol for an injection volume of 20 μL. The method has been used for the determinati...

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Veröffentlicht in:	Electroanalysis (New York, N.Y.) N.Y.), 1997-11, Vol.9 (16), p.1291-1293
Hauptverfasser:	Eriksson, Alf, Nyholm, Leif
Format:	Artikel
Sprache:	eng
Schlagworte:	3,3′‐Azobis‐(6‐bydroxy‐)benzoate 3′-Azobis-(6-bydroxy-)benzoate Electrochemical detection Olsalazine sodium Reversed phase liquid chromatography Solubility determinations
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Beschreibung
Zusammenfassung:	Electrochemical detection of disodium 3,3′‐azobis‐(6‐hydroxy‐)benzoate, olsalazine sodium, in reversed phase liquid chromatography is shown to provide a detection limit of 40 fmol and a linear range extending up to 4 nmol for an injection volume of 20 μL. The method has been used for the determination of the solubility of olsalazine sodium in aqueous solutions. The solubility was found to be 2 × 10−8 M and 4 × 10−6 M at pH 1.0 and 3.5, respectively.
ISSN:	1040-0397 1521-4109
DOI:	10.1002/elan.1140091615