Anti-inflammatory cyclohexenyl chalcone derivatives in Boesenbergia pandurata

The cyclohexenyl chalcone derivative [(−)-hydroxypanduratin A], together with the previously known panduratin A, sakuranetin, pinostrobin, pinocembrin, and dihydro-5,6-dehydrokawain were isolated from the chloroform extract of the red rhizome variety of Boesenbergia pandurata (Robx.) Schltr. [currently known as Boesenbergia rotunda (L.) Mansf., Kulturpfl.]. Their structures were assigned on the basis of their spectroscopic data. (−)-Hydroxypanduratin A and (−)-panduratin A showed significant topical anti-inflammatory activity in the assay of TPA-induced ear edema in rats. (−)-Hydroxypanduratin A, together with the known panduratin A, pinostrobin, pinocembrin, sakuranetin and dihydro-5,6-dehydrokawain have been isolated from the chloroform extract of the red rhizome variety of Boesenbergia pandurata (currently known as B. rotunda). Both (−)-hydroxypanduratin A and (−)-panduratin A showed significant topical anti-inflammatory activity in the assay of TPA-induced ear edema in rats.