Accumulation of plasma proteins in Purkinje cells as an indicator of blood-brain barrier breakdown

The transport of the extravasated proteins in the interstitial and/or cerebrospinal fluids and their accumulation into the Purkinje cells does require some time as does the disposal of the proteins from the cells. [...]the low number of fib+ Purkinje cells in the two cases with a history of epilepsy, could be due to so long a premortem seizure-free period that most of the uptaken fibrinogen had already been disposed. Remarkably, in our study many of the deceased persons without history of epilepsy had a considerable number of immunopositive Purkinje cells, more than half of them had over 10% of positive cells. [...]in the assessment of the premortem events and their significance for the person's SUD all the other diseases which cause BBB breakdown must be considered.