A Leukocyte Elastase Inhibitor Reduces Thrombin-Induced Pulmonary Oedema in the Rat: Mechanisms of Action

The effect of a selective leukocyte elastase inhibitor, ICI 200,355, on thrombin-induced pulmonary oedema was studied in rats. Thrombin administration produced an increase in lung weight (P

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Veröffentlicht in:	Pulmonary pharmacology & therapeutics 1998, Vol.11 (4), p.291-299
Hauptverfasser:	Ahn, C.M., Sandler, H., Saldeen, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Capillary Permeability - drug effects Disease Models, Animal Dose-Response Relationship, Drug Extracellular Matrix - pathology Leukocyte Elastase - antagonists & inhibitors Leukocyte elastase inhibitor, ICI 200,355, Thrombin, Microembolism, Rat, Pulmonary oedema, Myeloperoxidase, Adult respiratory distress syndrome Lung - drug effects Lung - enzymology Lung - pathology Male Oligopeptides - pharmacology Oligopeptides - therapeutic use Peroxidase - metabolism Pulmonary Edema - enzymology Pulmonary Edema - pathology Pulmonary Edema - prevention & control Rats Rats, Sprague-Dawley Respiratory Distress Syndrome, Adult - enzymology Respiratory Distress Syndrome, Adult - pathology Respiratory Distress Syndrome, Adult - prevention & control Serine Proteinase Inhibitors - pharmacology Serine Proteinase Inhibitors - therapeutic use Thrombin
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Zusammenfassung:	The effect of a selective leukocyte elastase inhibitor, ICI 200,355, on thrombin-induced pulmonary oedema was studied in rats. Thrombin administration produced an increase in lung weight (P
ISSN:	1094-5539 1522-9629 1522-9629
DOI:	10.1006/pupt.1998.9999