3-D Attention-SEV-Net for Segmentation of Post-operative Glioblastoma with Interactive Correction of Over-Segmentation

Accurate localization and volumetric quantification of post-operative glioblastoma are of profound importance for clinical applications like post-surgery treatment planning, monitoring of tumor regrowth, and radiotherapy map planning. Manual delineation consumes more time and error prone thus automated 3-D quantification of brain tumors using deep learning algorithms from MRI scans has been used in recent years. The shortcoming with automated segmentation is that it often over-segments or under-segments the tumor regions. An interactive deep-learning tool will enable radiologists to correct the over-segmented and under-segmented voxels. In this paper, we proposed a network named Attention-SEV-Net which outperforms state-of-the-art network architectures. We also developed an interactive graphical user interface, where the initial 3-D segmentation of contrast-enhanced tumor can be interactively corrected to remove falsely detected isolated tumor regions. Attention-SEV-Net is trained with BraTS-2021 training data set and tested on Uppsala University post-operative glioblastoma dataset. The methodology outperformed state-of-the-art networks like U-Net, V-Net, Attention U-Net and Residual U-Net. The mean dice score achieved is 0.6682 and the mean Hausdorff distance-95 got is 8.96 mm for the Uppsala University dataset.