Synthesis, Anti-inflammatory, and Neuroprotective Activity of N-Substituted Phthalimide Derivatives

Synthesis, Anti-inflammatory, and Neuroprotective Activity of N-Substituted Phthalimide Derivatives

A new series of N -substituted phthalimide compounds was synthesized in good yield. All the compounds were characterized by spectroscopic data and were evaluated for their inhibitory activity against the expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and pro-inflammat...

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Veröffentlicht in:Russian journal of general chemistry 2023-11, Vol.93 (11), p.2935-2940
Hauptverfasser: Bhat, M. A., Ahmed, A. F., Wen, Z.-H., El-Seedi, H. R., Naglah, A. M., Al-Omar, M. A.
Format: Artikel
Sprache:eng
Schlagworte:
6-OHDA
anti-inflammatory
Cell death
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
COX-2
Dexamethasone
iNOS
N-substituted phthalimides
neuroprotective
Nitric oxide
Phthalimides
Proteins
Substitutes
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Zusammenfassung:A new series of N -substituted phthalimide compounds was synthesized in good yield. All the compounds were characterized by spectroscopic data and were evaluated for their inhibitory activity against the expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and pro-inflammatory proteins in the bacterial lipopolysaccharide (LPS)-induced murine macrophage (RAW 264.7) cells. All the compounds significantly ( p
ISSN:1070-3632
1608-3350
1608-3350
DOI:10.1134/S1070363223110257