The Dynamics of Adaptation to Stress from Standing Genetic Variation and de novo Mutations

Adaptation from standing genetic variation is an important process underlying evolution in natural populations, but we rarely get the opportunity to observe the dynamics of fitness and genomic changes in real time. Here, we used experimental evolution and Pool-Seq to track the phenotypic and genomic...

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Veröffentlicht in:Molecular biology and evolution 2022-11, Vol.39 (11)
Hauptverfasser: Ament-Velásquez, Sandra Lorena, Gilchrist, Ciaran, Rêgo, Alexandre, Bendixsen, Devin P, Brice, Claire, Grosse-Sommer, Julie Michelle, Rafati, Nima, Stelkens, Rike
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Sprache:eng
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Zusammenfassung:Adaptation from standing genetic variation is an important process underlying evolution in natural populations, but we rarely get the opportunity to observe the dynamics of fitness and genomic changes in real time. Here, we used experimental evolution and Pool-Seq to track the phenotypic and genomic changes of genetically diverse asexual populations of the yeast Saccharomyces cerevisiae in four environments with different fitness costs. We found that populations rapidly and in parallel increased in fitness in stressful environments. In contrast, allele frequencies showed a range of trajectories, with some populations fixing all their ancestral variation in
ISSN:0737-4038
1537-1719
1537-1719
DOI:10.1093/molbev/msac242