Low‐grade diffusely infiltrative tumour (LGDIT), SMARCB1‐mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT‐MYC

Low‐grade diffusely infiltrative tumour (LGDIT), SMARCB1‐mutant, is a histopathological distinct low‐grade lesion encountered in older children and young adults that shows epigenetic similarity with ATRT‐MYC and has the potential for malignant progression.

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Veröffentlicht in:	Neuropathology and applied neurobiology 2022-06, Vol.48 (4), p.e12797-n/a
Hauptverfasser:	Hasselblatt, Martin, Thomas, Christian, Federico, Aniello, Bens, Susanne, Hellström, Mats, Casar‐Borota, Olivera, Kordes, Uwe, Neumann, Julia E., Dottermusch, Matthias, Rodriguez, Fausto J., Lo, Andrea C., Cheng, Sylvia, Hendson, Glenda, Hukin, Juliette, Hartmann, Christian, Koch, Arend, Capper, David, Siebert, Reiner, Paulus, Werner, Nemes, Karolina, Johann, Pascal D., Frühwald, Michael C., Kool, Marcel
Format:	Artikel
Sprache:	eng
Schlagworte:	atypical teratoid atypical teratoid/rhabdoid tumour central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency Child DNA methylation profiling Epigenesis, Genetic Epigenetics Humans Mutants neuropathology Rhabdoid Tumor - pathology rhabdoid tumour SMARCB1 Protein - genetics Teratoma Tumors Young Adult Young adults
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Zusammenfassung:	Low‐grade diffusely infiltrative tumour (LGDIT), SMARCB1‐mutant, is a histopathological distinct low‐grade lesion encountered in older children and young adults that shows epigenetic similarity with ATRT‐MYC and has the potential for malignant progression.
ISSN:	0305-1846 1365-2990 1365-2990
DOI:	10.1111/nan.12797