Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon

Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal Colon

Although somatic mutations in colorectal cancer are well characterized, little is known about the accumulation of cancer mutations in the normal colon before cancer. Here, we have developed and applied an ultrasensitive, single-molecule mutational test based on CRISPR-DS technology, which enables mu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer research (Chicago, Ill.) Ill.), 2022-04, Vol.82 (8), p.1492-1502
Hauptverfasser: Matas, Julia, Kohrn, Brendan, Fredrickson, Jeanne, Carter, Kelly, Yu, Ming, Wang, Ting, Gui, Xianyong, Soussi, Thierry, Moreno, Victor, Grady, William M, Peinado, Miguel A, Risques, Rosa Ana
Format: Artikel
Sprache:eng
Schlagworte:
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Genes, ras
Humans
Mutation
Proto-Oncogene Proteins p21(ras) - genetics
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Although somatic mutations in colorectal cancer are well characterized, little is known about the accumulation of cancer mutations in the normal colon before cancer. Here, we have developed and applied an ultrasensitive, single-molecule mutational test based on CRISPR-DS technology, which enables mutation detection at extremely low frequency (
ISSN:0008-5472
1538-7445
1538-7445
DOI:10.1158/0008-5472.CAN-21-3607