PharmVar GeneFocus: CYP2C9

The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C9 gene. Genetic variation within the CYP2C9 gene locus impacts the metabolism or bioactivation of many clinically important drugs, including nonsteroidal anti‐inflammatory drugs, p...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2021-09, Vol.110 (3), p.662-676
Hauptverfasser:	Sangkuhl, Katrin, Claudio‐Campos, Karla, Cavallari, Larisa H., Agundez, Jose A.G., Whirl‐Carrillo, Michelle, Duconge, Jorge, Del Tredici, Andria L., Wadelius, Mia, Rodrigues Botton, Mariana, Woodahl, Erica L., Scott, Stuart A., Klein, Teri E., Pratt, Victoria M., Daly, Ann K., Gaedigk, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Clinical Pharmacology Cytochrome P-450 CYP2C9 - genetics Haplotypes - genetics Humans Klinisk farmakologi Knowledge Bases Pharmaceutical Preparations - administration & dosage Pharmacogenetics - methods Polymorphism, Genetic - genetics
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Beschreibung
Zusammenfassung:	The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C9 gene. Genetic variation within the CYP2C9 gene locus impacts the metabolism or bioactivation of many clinically important drugs, including nonsteroidal anti‐inflammatory drugs, phenytoin, antidiabetic agents, and angiotensin receptor blockers. Variable CYP2C9 activity is of particular importance regarding efficacy and safety of warfarin and siponimod as indicated in their package inserts. This GeneFocus provides a comprehensive overview and summary of CYP2C9 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium.
ISSN:	0009-9236 1532-6535 1532-6535
DOI:	10.1002/cpt.2333