Inhibitory effect of Siwei Xiaoliuyin on glioma angiogenesis in nude mice

Objective: Application of Siwei Xiaoliuyin in glioma mice. Explore the effect of Siwei Xiaoliuyin on angiogenesis of nude mice glioma and its mechanism. Methods: Establish human glioma cell line U87 tumor model. Mice were randomized to the saline group, the conventional dose of Siwei Xiaoliuyin, hig...

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Veröffentlicht in:	International review of neurobiology 2020, Vol.151, p.243-252
Hauptverfasser:	Zhang, Zhiqiang, Zhan, Wengang, Chen, Huijing, Chen, Yun, Li, Cong, Yang, Yanying, Tan, Qijia, Xie, Caijun, Sharma, Hari Shanker, Sharma, Aruna
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Chinese medicine treatment Glioma Nude mice
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Zusammenfassung:	Objective: Application of Siwei Xiaoliuyin in glioma mice. Explore the effect of Siwei Xiaoliuyin on angiogenesis of nude mice glioma and its mechanism. Methods: Establish human glioma cell line U87 tumor model. Mice were randomized to the saline group, the conventional dose of Siwei Xiaoliuyin, high dose group of Siwei Xiaoliuyin, TMZ group, combination therapy group, record the tumor volume. Using the method of Weidner counted the microvessel density. ELISA enzyme-linked adsorption method to detect the content of nude mice serum VEGF and ES. The difference was statistically significant (P
ISSN:	0074-7742 2162-5514
DOI:	10.1016/bs.irn.2020.03.008