Circulating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N‐terminal pro‐B‐type natriuretic peptide and high‐sensitivity troponin T

Aims N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), high‐sensitivity troponin T (hs‐TnT) and soluble suppression of tumorigenesis‐2 (sST2) predict outcome in chronic heart failure (HF). We assessed the influence of age on circulating levels and prognostic significance of these biomarkers. Me...

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Veröffentlicht in:	European journal of heart failure 2020-11, Vol.22 (11), p.2078-2088
Hauptverfasser:	Aimo, Alberto, Januzzi, James L., Vergaro, Giuseppe, Richards, A. Mark, Lam, Carolyn S.P., Latini, Roberto, Anand, Inder S., Cohn, Jay N., Ueland, Thor, Gullestad, Lars, Aukrust, Pål, Brunner‐La Rocca, Hans‐Peter, Bayes‐Genis, Antoni, Lupón, Josep, Boer, Rudolf A., Takeishi, Yasuchika, Egstrup, Michael, Gustafsson, Ida, Gaggin, Hanna K., Eggers, Kai M., Huber, Kurt, Gamble, Greg D., Ling, Lieng H., Leong, Kui Tong Gerard, Yeo, Poh Shuah Daniel, Ong, Hean Yee, Jaufeerally, Fazlur, Ng, Tze P., Troughton, Richard, Doughty, Robert N., Passino, Claudio, Emdin, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Basale medisinske, odontologiske og veterinærmedisinske fag: 710 Basic medical, dental and veterinary science disciplines: 710 Biomarkers Heart failure Medical disciplines: 700 Medisinske Fag: 700 Prognosis sST2 VDP
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Zusammenfassung:	Aims N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), high‐sensitivity troponin T (hs‐TnT) and soluble suppression of tumorigenesis‐2 (sST2) predict outcome in chronic heart failure (HF). We assessed the influence of age on circulating levels and prognostic significance of these biomarkers. Methods and results Individual data from 5301 patients with chronic HF and NT‐proBNP, hs‐TnT, and sST2 data were evaluated. Patients were stratified according to age:
ISSN:	1388-9842 1879-0844 1879-0844
DOI:	10.1002/ejhf.1701