Randomized Trial of Amoxicillin for Pneumonia in Pakistan

Randomized Trial of Amoxicillin for Pneumonia in Pakistan

The WHO recommends oral amoxicillin for pneumonia with tachypnea, yet trial data show that withholding amoxicillin may be noninferior to using amoxicillin. In this double-blind trial, children 2 to 59 months of age in low-income communities in Pakistan were assigned to a 3-day course of placebo or a...

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Veröffentlicht in:The New England journal of medicine 2020-07, Vol.383 (1), p.24-34
Hauptverfasser: Jehan, Fyezah, Nisar, Imran, Kerai, Salima, Balouch, Benazir, Brown, Nick, Rahman, Najeeb, Rizvi, Arjumand, Shafiq, Yasir, Zaidi, Anita K.M
Format: Artikel
Sprache:eng
Schlagworte:
Age
Amoxicillin
Antibiotics
Children
Clinical trials
Fever
HIV
Human immunodeficiency virus
Infections
Low income groups
Medical research
Oxygen saturation
Pathogens
Patients
Penicillin
Pneumonia
Primary care
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Zusammenfassung:The WHO recommends oral amoxicillin for pneumonia with tachypnea, yet trial data show that withholding amoxicillin may be noninferior to using amoxicillin. In this double-blind trial, children 2 to 59 months of age in low-income communities in Pakistan were assigned to a 3-day course of placebo or amoxicillin. The noninferiority of placebo was not shown.
ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1911998