Comment on “Target-Controlled Continuous Infusion for Antibiotic Dosing: Proof-of-Principle in an In-silico Vancomycin Trial in Intensive Care Unit Patients”

[...]dosing adaptations based on target attainment at the site of infection would be desirable. [...]Colin and colleagues chose a populationPK model for their TCI system that was based on a large dataset (nID = 398) spanning broad patient characteristics, and had been subjected to extensive validation after model development. For reliable recommendations on initial vancomycin doses, which are determined solely based on dosing history and relevant available patient characteristics, total body weight and creatinine clearance seem to play a vital role: the covariates were included both in the aTCI model [1], which led to the overall highest PTA of all investigated dosing regimens, as well as in the best predictive model in the above-mentioned model comparison [7].